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Medchemexpress LLC Prazosin (hydrochloride) | 19237-84-4 | 1 ML
Supplier: Medchemexpress LLC HYB0193A10MM/1ML
Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist used for research of high blood pressure and alcohol use disorders. It potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM and inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8 and 13 μM.
- CNS-active α1-adrenergic receptor antagonist
- Research for high blood pressure and alcohol use disorders
- Potently inhibits norepinephrine (NE)-stimulated 45Ca efflux (IC50 = 0.15 nM)
- Inhibits organic cation transporters OCT-1 and OCT-3 (IC50s = 1.8, 13 μM)
- Effectively inhibits proliferation, migration, and invasion of U251 and U87 cells
- Decreases protein expression of PI3K/AKT/mTOR signaling pathway components
- Suppresses central α1-adrenergic-mediated hyperexcitability and stress-induced anxiety
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