Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Vector Biolabs Glycogen synthase kinase 3 alpha Adenovirus (Ad-GSK3A)
Supplier: Vector Biolabs 1424
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine, proline directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion and is implicated in Alzheimer's disease. Two forms of GSK-3, designated GSK-3(alpha) and GSK-3(beta), are related yet they differ in their subcellular localization. The microtubule binding protein, Tau, serves to stabilize microtubules in growing axons. Tau is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer's disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3, presenting the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer's disease.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?