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Vector Biolabs Superoxide dismutase 1, soluble Adenovirus (Ad-SOD1)
Supplier: Vector Biolabs 1503
The superoxide dismutase family is composed of three metalloenzymes (SOD-1, SOD-2 and SOD-3) that catalyze the oxido-reduction of reactive oxygen species (ROS) such as superoxide anion. Unlike SOD-1, which is a homodimeric cytosolic Cu-Zn enzyme, SOD-2 is a 22 kDa homotetrameric manganese enzyme (also known as MnSOD) that functions in the mitochondrion. SOD-1 activity depends on the delivery of copper cofactors by Copper chaperone for SOD-1 (CCS). CCS prevents copper ions from binding to intracellular scavengers, thus securing copper for SOD-1.
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