Cayman Chemical Prenylamn 10mg

Supplier:  Cayman Chemical 2943010 MG

A calcium channel inhibitor; inhibits PMCA in isolated and purified pig cardiac sarcolemma; binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 µM and inhibits CaM-activated cAMP PDE activity at 10-50 µM, an effect that is negatively associated with the concentration of calmodulin; shortens action potentials and decreases the inward calcium current in single guinea pig ventricular myocytes in the absence and presence of propranolol and phentolamine at 30 μM; decreases epinephrine, serotonin, and dopamine levels in rat brain at 50 mg/kg; decreases epinephrine levels in rat heart; protects anesthetized rats from coronary artery occlusion-induced arrhythmia at 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole at 5 mg/kg

Catalog No. 50-298-8900