Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Prexasertib (dihydrochloride) | 1234015-54-3 | 99.4% | 438.31 | 5 MG
Supplier: Medchemexpress LLC HY18174A5MG
Prexasertib dihydrochloride (LY2606368 dihydrochloride) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. It also inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). This compound causes double-stranded DNA breakage and replication catastrophe leading to apoptosis and shows potent anti-tumor activity.
- Selective ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor.
- Inhibits CHK2 and RSK1.
- Causes double-stranded DNA breakage and replication catastrophe.
- Leads to apoptosis and potent anti-tumor activity.
- Induces growth inhibition in tumor xenografts.
- Inhibits CHK1 in blood.
- Promotes phosphorylation of H2AX (S139) and RPA2 (S4/S8).
- Associated with clinical trials for various neoplasms.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?