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Apexbio Technology LLC PRIMA-1MET 5291-32-7 10mg
Supplier: Apexbio Technology LLC A448410
PRIMA-1MET (CAS 5291-32-7) is a methylated derivative of PRIMA-1 developed to selectively restore the function of mutant p53 protein in tumor cells p53 encoded by the TP53 gene serves as a crucial regulator of the cell cycle apoptosis and genomic stability and is frequently mutated in human cancers leading to impaired apoptosis and uncontrolled proliferation PRIMA-1MET has demonstrated the ability to bind directly to mutant p53 reactivate its transcriptional activity and induce the expression of downstream targets associated with apoptosis and cell cycle arrest In cellular models PRIMA-1MET promoted mitochondrial apoptosis through caspase-2 activation and enhanced the cytotoxicity of chemotherapeutic agents such as cisplatin These properties make PRIMA-1MET a valuable tool for investigating mutant p53 reactivation in cancer research
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