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Cayman Chemical PrInomastat 10mg
Supplier: Cayman Chemical 3769910 MG
An inhibitor of MMP-2, -3, -9, -13, and -14 (IC50s = 0.05, 0.3, 0.26, 0.03, and 0.33 nM, respectively); selective for these MMPs over MMP-1 and MMP-7 (IC50s = 8.3 and 54 nM, respectively); reduces tumor growth and inhibits the formation of lung metastases in a murine Lewis lung carcinoma model at 50 mg/kg; reduces the incidence of lung metastasis and tumor microvessel density in an NCI H460 lung cancer orthotopic mouse model at 100 mg/kg; reduces BALF levels of TNF-α and pulmonary edema in a rat model of ventilator-induced lung injury
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