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Medchemexpress LLC Prochloraz | 67747-09-5 | 99.85% | 1 G
Supplier: Medchemexpress LLC HYB08451G
Prochloraz is an imidazole antifungal that functions as an estrogen receptor (ER) and androgen receptor (AR) antagonist, and an aromatase inhibitor. It strongly inhibits the microsomal cytochrome P-450 dependent 14α-demethylation of lanosterol during ergosterol biosynthesis, leading to membrane disruption and eventual cell death. In vivo, it acts as an antiandrogen by reducing reproductive organ weights, affecting androgen-regulated gene expression in the prostate, and increasing luteinizing hormone levels.
- Acts as an estrogen receptor (ER) and androgen receptor (AR) antagonist
- Functions as an aromatase inhibitor
- Activates the aryl hydrocarbon receptor (AhR)
- Inhibits ergosterol biosynthesis
- Causes membrane disruption and cell death
- Reduces reproductive organ weights in vivo
- Affects androgen-regulated gene expressions in the prostate
- Increases luteinizing hormone levels
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