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Medchemexpress LLC Propargyl-PEG1-acid | 55683-37-9 | 97.0% | 1 G
Supplier: Medchemexpress LLC HY1305041G
Propargyl-PEG1-acid is a PEG-based PROTAC linker. It is utilized in the synthesis of BTK-CRBN PROTACs, including Ibrutinib-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM. This product also functions as a click chemistry reagent, containing an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Functions as a PEG-based PROTAC linker
- Utilized in the synthesis of BTK-CRBN PROTACs
- Acts as a click chemistry reagent
- Contains an alkyne group for copper-catalyzed azide-alkyne cycloaddition
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