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Medchemexpress LLC Propargyl-PEG6-N3 | 1198080-03-3 | 250 MG
Supplier: Medchemexpress LLC 250MGHY130183
Propargyl-PEG6-N3 is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This compound functions as a click chemistry reagent, containing an Azide group. It can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules that possess Alkyne groups, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs are designed with two distinct ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other a target protein, enabling the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- Peg-based protac linker
- Used in protac synthesis
- Click chemistry reagent
- Contains an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC)
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