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Medchemexpress LLC Protac Bcl2 degrader-1 | 2378801-85-3 | 99.8% | 941.84 | C45H45BrN6O10S | 1MG
Supplier: Medchemexpress LLC HY1258761MG
PROTAC Bcl2 degrader-1 is a cereblon-based proteolysis targeting chimera (PROTAC) designed to induce ubiquitin-proteasome mediated degradation of antiapoptotic Bcl-2 family proteins. It is intended for cellular research into targeted protein degradation, apoptosis pathways, and mechanism-of-action studies; manufacturer data provide bioactivity, solubility, purity, and storage guidance to support experimental planning.
- Cereblon-based PROTAC that recruits CRBN E3 ligase.
- Induces selective degradation of Bcl-2 and Mcl-1 in cell assays.
- Reported bioactivity: Bcl-2 DC50 3 μM, Bcl-2 IC50 4.94 μM, Mcl-1 IC50 11.81 μM.
- Molecular formula C45H45BrN6O10S and molecular weight 941.84.
- High purity (99.8%) suitable for research use.
- Soluble in DMSO (≈25 mg/mL) and compatible with common in vivo formulations.
- Store at -20°C under inert atmosphere; in solvent store at -80°C for long term.
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