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Medchemexpress LLC PROTAC Bcl2 degrader-1 | 2378801-85-3 | 99.8% | 941.84 g/mol | C45H45BrN6O10S | 5MG
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Supplier:  Medchemexpress LLC HY1258765MG

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PROTAC Bcl2 degrader-1 is a cereblon-based PROTAC that selectively induces degradation of anti-apoptotic proteins Bcl-2 and Mcl-1 by recruiting the CRBN E3 ligase. Supplied for research use only as a high-purity solid, it is intended for biochemical and cellular studies of targeted protein degradation and apoptosis.

  • Potent degrader of Bcl-2 and Mcl-1 (Bcl-2 DC50 3 μM; IC50 4.94 μM; Mcl-1 IC50 11.81 μM).
  • High purity for research use (99.8%).
  • Soluble in DMSO up to 25 mg/mL; in vivo vehicle formulations reported.
  • Well characterized molecular properties (MW 941.84 g/mol; formula C45H45BrN6O10S).
  • Storage conditions provided to preserve stability (-80°C in solvent for up to 6 months; -20°C for short term).

Catalog No. 50-002-37848


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