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Medchemexpress LLC PROTAC CDK2/9 Degrader-1 | 2408641-24-5 | 99.9% | 50 MG
Supplier: Medchemexpress LLC HY13070950MG
PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM). It suppresses prostate cancer PC-3 cell proliferation (IC50=0.12 μM) by effectively blocking the cell cycle in S and G2/M phases. This compound is a PROTAC that functions by tethering a CDK inhibitor with a Cereblon ligand.
- Potent dual degrader for CDK2 and CDK9
- Suppresses prostate cancer PC-3 cell proliferation
- Functions by tethering a CDK inhibitor with a Cereblon ligand
- Induces cell cycle blockage at the G2/M phase
- Down-regulates Mcl-1 protein level
- Effectively degrades CDK2/9 in various cell lines
- Inhibits both CDK2 and CDK9
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