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Medchemexpress LLC PROTAC EGFR degrader 7 | 3033297-59-2 | 99.99% | 836.94 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1478585MG

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PROTAC EGFR degrader 7 (compound 13b) is a potent and selective CRBN-recruiting PROTAC EGFRL858R/T790M degrader, with a DC50 of 13.2 nM. It inhibits NCI-H1975 cells proliferation with an IC50 of 46.82 nM. This product significantly induces apoptosis and G2/M phase arrest in NCI-H1975 cells and shows antitumor activity, making it suitable for non-small cell lung cancer (NSCLC) research. Additionally, it is a click chemistry reagent containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

  • Potent and selective CRBN-recruiting PROTAC EGFRL858R/T790M degrader
  • Inhibits NCI-H1975 cells proliferation
  • Induces apoptosis and G2/M phase arrest in NCI-H1975 cells
  • Shows antitumor activity for non-small cell lung cancer (NSCLC) research
  • Click chemistry reagent containing an Alkyne group

Catalog No. 50-003-59812


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