Medchemexpress LLC PROTAC ERRα Degrader-3 | 2306388-65-6 | 98.8% | 956.99 | 50 MG

Supplier:  Medchemexpress LLC HY13918550MG

PROTAC ERRα Degrader-3 is a potent and selective ERRα degrader based on a von Hippel-Lindau ligand. It can specifically degrade ERRα protein by more than 80% at a concentration of 30 nM and is inactive against ERRβ and ERRγ proteins. It induces ERRα degradation dose-dependently with an efficacious dose as low as 3.0 nM at 4.0 h, also decreasing levels of downstream target genes like ATP5B, MCAD, and PDK4.

• Potent and selective ERRα degrader
• Based on von Hippel-Lindau ligand
• Specifically degrades ERRα protein by >80% at 30 nM
• Inactive against ERRβ and ERRγ proteins
• Induces ERRα degradation dose-dependently from 0.3 nM to 10 μM within 4 hours
• Decreases protein levels of ERRα downstream target genes (ATP5B, MCAD, PDK4)
• Exhibits an IC50 value of 12.67 nM for blocking ERRα with PGC-1α peptide interaction
• Induces approximately 96% protein degradation at 100 nM after 4.0 h treatment

Catalog No. 50-003-50003