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Medchemexpress LLC Protac PD-1/PD-L1 degrader-1 | 2447066-37-5 | 99.5% | C59H58ClN7O11 | 10MG
Supplier: Medchemexpress LLC HY13118310MG
PROTAC PD-1/PD-L1 degrader-1 is a cereblon-based proteolysis targeting chimera designed to disrupt PD-1/PD-L1 interaction and induce degradation of PD-L1 in cells. It demonstrates potent cellular activity and has been applied in co-culture models to restore immune responses via a lysosome-dependent mechanism.
- High purity suitable for cellular and biochemical assays.
- Potent cellular activity (IC50 39.2 nM).
- Cereblon E3 ligase-mediated degradation mechanism.
- Reduces PD-L1 protein levels in a lysosome-dependent manner.
- Suitable for studies of immune checkpoint modulation and PD-L1 biology.
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