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Cayman Chemical PROTAC RAF Degrader 1 1mg
SDP

Supplier:  Cayman Chemical 409671 MG

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A PROTAC; selectively induces the degradation of B-RAFV600E over wild-type B-RAF in SK-MEL-239 cells at 10 to 1,000 nM; inhibits wild-type B-RAF and a panel of mutant B-RAF isoforms (IC50s = 5.8 and 1.87 nM); reduces the viability of SK-MEL-28, SK-MEL-239, and SK-MEL-246 melanoma cells (EC50s = 215, 37, and 243 nM, respectively); reduces tumor growth and volume in an SK-MEL-246 mouse xenograft model at 50 mg/kg twice per day

Catalog No. 50-294-4818


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