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Medchemexpress LLC PROTAC STING Degrader-1 | 2762552-74-7 | C34H33N7O10 | 1 MG
Supplier: Medchemexpress LLC HY1506081MG
PROTAC STING Degrader-1 is a PROTAC degrader targeting the STING pathway with a DC50 of 3.2 μM. It demonstrates high anti-inflammatory efficacy and can be utilized for studying conditions such as acute kidney injury and inflammatory bowel diseases (IBDs). The compound consists of a STING ligand, a CRBN ligand, and a linker.
- Degrades STING in a dose- and time-dependent manner
- Downregulates downstream signals of the STING pathway
- Shows no cytotoxicity in LO2, HEK293A, and C17.2 at doses below 10 μM
- Alleviates ischemic symptoms and reduces kidney weights in acute kidney injury models
- Ameliorates the severity of DSS-induced colitis
- Reduces the production of proinflammatory cytokines and transcription of ISGs
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