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Medchemexpress LLC PRT062607 | 1370261-96-3 | C19H23N9O | 50 MG
Supplier: Medchemexpress LLC HY1532250MG
PRT062607 is an orally active ATP-competitive Syk inhibitor with an IC50 of 1 nM, demonstrating at least 80-fold selectivity over other kinases. It blocks B cell antigen receptor-mediated activation, Fcε receptor 1-mediated basophil degranulation and microglial phagocytosis, and induces caspase-dependent apoptosis and microglial death. It inhibits tumor growth and peripheral nerve injury-induced mechanical allodynia, and prevents neuronal loss.
- Blocks B cell antigen receptor-mediated activation, Fcε receptor 1-mediated basophil degranulation, and microglial phagocytosis.
- Induces caspase-dependent apoptosis and microglial death.
- Inhibits tumor growth and peripheral nerve injury-induced mechanical allodynia.
- Prevents neuronal loss.
- Used in research for rheumatoid arthritis, chronic lymphocytic leukemia, non-Hodgkin's lymphoma, neurodegenerative diseases, and neuropathic pain.
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