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Medchemexpress LLC PRT062607 Hydrochloride | 1370261-97-4 | 98.07% | 429.91 | 50 MG
Supplier: Medchemexpress LLC 50MGHY15323
PRT062607 Hydrochloride is an orally available Syk inhibitor that effectively inhibits inflammation and induces apoptosis. It demonstrates potent antitumor activity in tumor xenograft mouse models. This compound inhibits phosphorylation of ERK, AKT, and SYK in Ramos cells, and BLNK Tyr84 phosphorylation in a concentration-dependent manner.
- Inhibits B cell antigen receptor-mediated B cell signaling and activation
- Inhibits Fc receptor 1-mediated induced basophil degranulation
- Produces dose-dependent anti-inflammatory activity in rodent models of rheumatoid arthritis
- Prevents BCR-induced splenomegaly in mice
- Prevents Ramos tumor formation in mouse xenograft models
- Significantly inhibits NHL tumor growth in xenograft models
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