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ATCC PSN-1; Pancreas Adenocarcinoma; Human (Homo sapiens)
Supplier: ATCC CRL3211
PSN-1 is a cell line exhibiting epithelial-like morphology isolated from the pancreas of a patient with adenocarcinoma. After transplantation into nude mice the PSN1 cell line was established from the xenograft. PSN1 cells are unique in that amplification of both c-myc (50-fold) and activated c-Ki-ras (3-6 fold) with a point mutation from GGT to CGT at codon 12 are present in the same degree as in the original tumour and contain increased amounts of c-myc and c-Ki-ras transcripts. Loss of one of the two p53 alleles and a point mutation from AAG to CAG at codon 132 in the remaining allele was also observed in PSN1.
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