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Apexbio Technology LLC PT 1 331002-70-1 25mg
SDP

Supplier:  Apexbio Technology LLC B757225

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PT 1 (CAS 331002-70-1) is a selective activator of AMP-activated protein kinase (AMPK) a serine/threonine kinase central to cellular energy homeostasis PT 1 preferentially activates the AMPK 1 1 1 isoform with an EC50 of 0 3 M and also stimulates other AMPK complexes including truncated forms of the subunit containing the autoinhibitory domain In cellular studies PT 1 increases phosphorylation of AMPK and its downstream target ACC independently of LKB1 reduces triacylglycerol and cholesterol accumulation in HepG2 cells and enhances AMPK-dependent signaling PT 1 serves as a valuable tool for probing AMPK activation and metabolic regulation in cellular and biochemical research settings

Catalog No. 50-000-87843


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