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Medchemexpress LLC PT-65 | GSK3α/GSK3β PROTAC degrader | 2721998-87-2 | C51H63N13O12S | 1 ML
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Supplier:  Medchemexpress LLC HY15316610MM/1ML

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PT-65 is a PROTAC degrader targeting both GSK3α and GSK3β, with DC50 values of 28.3 nM and 34.2 nM, respectively. It works by inhibiting excessive tau phosphorylation, which is mediated by GSK3β, Aβ, and Okadaic acid. PT-65 is considered applicable for research related to Alzheimer's disease.

  • Dose-dependently reduces GSK3β-mediated tau hyperphosphorylation at serine 396, serine 404, and threonine 205 sites by inducing GSK3β degradation.
  • Protects SH-SY5Y cells from Aβ42-induced neurotoxicity by reducing GSK3 levels and subsequent tau hyperphosphorylation.
  • Ameliorates okadaic acid-induced learning and memory impairments in male Sprague-Dawley rats.
  • Reduces hippocampal GSK3α/β levels and tau hyperphosphorylation in vivo.

Catalog No. 50-003-73447


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