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Medchemexpress LLC Purmorphamine | 483367-10-8 | C31H32N6O2 | 100 MG
Supplier: Medchemexpress LLC HY15108100MG
Purmorphamine is a potent smoothened/Smo receptor agonist with an EC50 of 1 μM and an IC50 of 1.5 μM for Smoothened. It is intended for research use only and not for human or animal therapeutic use. This compound promotes osteoblast differentiation and up-regulates key markers of the osteoblast phenotype, demonstrating its utility in studying bone development and related cellular processes.
- Acts as a smoothened/Smo receptor agonist
- Induces osteoblast differentiation
- Up-regulates alkaline phosphatase activity and RUNX-2 expression
- Up-regulates osteocalcin at specific doses
- Induces STAT3 phosphorylation
- Promotes bone-like nodule formation in human bone marrow mesenchymal cells
- Significantly decreases cell numbers in combination with sirolimus
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