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Sigma Aldrich Fine Chemicals Biosciences Puromycin ready made solut
Supplier: Sigma Aldrich Fine Chemicals Biosciences P45121MLX10
Puromycin is an aminonucleoside antibiotic naturally produced by Streptomyces alboniger as a tyrosyl tRNA analog. It inhibits ribosomal protein synthesis process by causing premature chain termination acting as an analog of the 3prime-terminal end of the aminoacyl-tRNA. Puromycin also acts as a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase (100muM IC500.6muM). Puromycin is used as a selection marker gene (puromycin-N-acetyltransferase gene pac) in eukaryotic/mammalian cells.Puromycin has a wide variety of biological activities with inhibitory effect against bacteria protozoa parasitic worms algae plants and mammalian cells.Puromycin shows broad spectrum activity particularly strong activity against gram positive microorganisms but weak activity against acid-fast bacilli and even weaker activity against gram negative microorganisms.Puromycin has anti-cancer properties inducing apoptosis in breast cancer cells. It has been s
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