ABclonal Technology PVRL1/NECTIN1 Rabbit mAb

Supplier:  ABclonal Technology A2499220UL

This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells The protein is a calcium(2 )-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops a single transmembrane domain (in some isoforms) and a cytoplasmic region This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1 HSV-2) and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells Mutations in this gene cause cleft lip and palate ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL P) Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini

Catalog No. 50-000-12789