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Apexbio Technology LLC PX 12 141400-58-0 10mg
Supplier: Apexbio Technology LLC A450910
PX 12 is a small-molecule inhibitor targeting thioredoxin-1 (Trx-1) It is designed to modulate cellular redox processes by inhibiting Trx-1 thereby regulating redox-sensitive signaling pathways and transcription factor activity PX 12 exerts its biological activity primarily through inhibition of Trx-1 interfering with cellular responses to hypoxia by reducing HIF-1 stabilization and subsequent VEGF expression In in vitro studies and tumor xenograft models including HT-29 and MCF-7 cell lines PX 12 demonstrates inhibitory activity Based on these pharmacological properties PX 12 holds research potential in studies of redox-regulated intracellular signaling tumor angiogenesis and vascular permeability modulation in cancer biology
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