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Medchemexpress LLC PXS-5120A | 2125955-70-4 | 98.1% | 50 MG
SDP

Supplier:  Medchemexpress LLC HY13024250MG

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PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. It demonstrates high selectivity for LOXL2 over LOXL and effectively inhibits various forms of LOXL2, LOXL3, and LOXL4.

  • Potent, irreversible fluoroallylamine inhibitor
  • Exhibits anti-fibrotic activity
  • Highly selective for LOXL2 (Ki of 83 nM; pIC50 of 8.4) over LOXL (pIC50 of 5.8)
  • Inhibits recombinant human, fibroblast, mouse, and rat LOXL2, as well as human LOXL3 and LOXL4
  • Readily absorbed following oral gavage in vivo with prolonged plasma concentrations

Catalog No. 50-003-38573


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