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Medchemexpress LLC PXS-5505 anhydrous | 2409964-23-2 | 99.9% | 353.24 | 100 MG
Supplier: Medchemexpress LLC HY138625A100MG
PXS-5505 anhydrous (LOX-IN-3 dihydrochloride) is an orally active lysyl oxidase (LOX) inhibitor. It is used for research in fibrosis, cancer, and angiogenesis. This compound inhibits bovine LOX and human LOXL2 activities, and has demonstrated efficacy in reducing kidney and lung fibrosis in various animal models.
- Inhibits bovine LOX and human LOXL2 activities
- Exhibits sustained inhibition of LOXL1 and LOXL2
- Less active against SSAO/VAP-1 and MAO-B activities
- Abolishes lysyl oxidase activity in rats
- Reduces kidney fibrosis in unilateral ureteric obstruction (UUO) mice models
- Reduces lung fibrosis in Bleomycin-induced lung fibrosis model in C57Bl/6 mice
- For research use only
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