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Medchemexpress LLC PXS-6302 hydrochloride | 2584947-79-3 | C10H11ClF3NO2S | 100 MG
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Supplier:  Medchemexpress LLC HY151499A100MG

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PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor with IC50s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), and 0.3 μM (rh LOXL4). It features skin penetrability, reduces collagen deposition, and improves scar appearance. It also demonstrates high permeability across Caco-2 or MDCKII cells. In In Vivo studies, PXS-6302 hydrochloride inhibits LOX, reduces crosslinking, and improves scar appearance in porcine models. Topical application reduced collagen deposition and cross-linking in murine models, and significantly improved scar appearance in porcine injury models without reducing tissue strength.

  • Irreversible lysyl oxidase inhibitor
  • Readily skin penetrability
  • Reduces collagen deposition
  • Significantly improves scar appearance
  • High permeability across Caco-2 or MDCKII cells
  • Effective in murine and porcine models of injury and fibrosis

Catalog No. 50-003-72197


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