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Lonza Walkersville PyroCell Monocyte Activation Test – Human Serum (HS) Rapid System contains: cryopreserved, pooled PBMC (human, pMAT Cells), Human Serum Supplement, PeliKine Human IL-6 ELISA Rapid Kit, for 288 tests
Supplier: Lonza Walkersville 00296408
The Monocyte Activation Test (MAT) is an in vitro assay for pyrogen testing in pharmaceutical and medical device industries. The principle of the Monocyte Activation Test is based on the detection of inflammatory cytokines released by human monocytes in response to exogenous endotoxins (LPS) and non-endotoxin pyrogens (NEP). Since its first adoption by the European Pharmacopeia in 2010 (Ph. Eur. chapter 2.6.30) the Monocyte Activation Test is recognized as a compendial method for pyrogen testing in several world regions including Europe. Here, the Monocyte Activation Test is suggested to replace the Rabbit Pyrogen Test (RPT). The Monocyte Activation Test is further compliant to the EU Directive 2010/63/EU on the protection of experimental animals.
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