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Lonza Walkersville PyroCell Monocyte Activation Test - Human Serum Kit - 3 vials cryopreserved, pooled PBMC (human, pMAT cells), 3 vials of cryopreserved Human Serum Supplement, for 288 tests (3x 96-well plates).
Supplier: Lonza Walkersville 00279770
The Monocyte Activation Test (MAT) is an in vitro assay for pyrogen testing in pharmaceutical and medical device industries. The principle of the Monocyte Activation Test is based on the detection of inflammatory cytokines released by human monocytes in response to exogenous bacterial endotoxin (LPS) and non-endotoxin pyrogens (NEP). Since its first adoption by the European Pharmacopeia in 2010 (Ph. Eur. chapter 2.6.30) the Monocyte Activation Test is recognized as a compendial method for pyrogen testing in several world regions including Europe. Here, the Monocyte Activation Test is recommended as a replacement test for the Rabbit Pyrogen Test (RPT). Here, the Monocyte Activation Test is the compendial method for pyrogen testing following the discontinuation of the Rabbit Pyrogen Test. The Monocyte Activation Test also complies with EU Directive 2010/63/EU on the protection of experimental animals.
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