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Cayman Chemical PyrotInIbmaleate 10mg
Supplier: Cayman Chemical 4210810 MG
An EGFR and HER2 inhibitor (IC50s = 13 and 38 nM, respectively); selectively inhibits the proliferation of HER2+ BT474 and SKOV3 cells (IC50s = 5.1 and 43 nM, respectively) over HER2- MDA-MB-231 cells (IC50 = 3,500 nM); decreases tumor growth without affecting body weight in BT474 and SKOV3 mouse xenograft models at 10 mg/kg per day
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