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Apexbio Technology LLC Pyroxamide 382180-17-8 5mg
Supplier: Apexbio Technology LLC A44975
Pyroxamide (CAS 382180-17-8) is a small molecule inhibitor of histone deacetylases (HDACs) with demonstrated inhibitory activity against HDAC1 (ID50 100 nM) By blocking HDAC-mediated deacetylation of histone lysine residues pyroxamide increases histone acetylation levels thereby affecting chromatin structure and transcriptional regulation In murine erythroleukemia (MEL) cells it induces terminal differentiation and suppresses proliferation via apoptosis or cell cycle arrest and elevates acetylated histones H2A H2B H3 and H4 In rhabdomyosarcoma cell lines pyroxamide increases p21/WAF1 expression promotes apoptosis and leads to histone acetylation In vivo it significantly reduces tumor growth in prostate cancer xenograft models Pyroxamide is thus a valuable tool for investigating epigenetic modulation and cancer biology
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