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Medchemexpress LLC QO-40 | 1259536-70-3 | 98.8% | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY130070

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QO-40, a pyrazolo[1,5-a]pyrimidine-7(4H)-one (PPO) derivative, is a KCNQ2/KCNQ3 K+ channels activator with an EC50 of 6.94 μM. It also stimulates Ca2+-activated K+ current (IK(Ca)) with an EC50 value of 2.3 μM in pituitary GH3 lactotrophs. For research use only, QO-40 increases KCNQ2/3 currents and potently augments KCNQ2/3 channels expressed in Chinese hamster ovary cells, shifting the half-maximal activation voltage (V(1/2)) in the hyperpolarizing direction.

  • Activates KCNQ2/KCNQ3 K+ channels.
  • Stimulates Ca2+-activated K+ current (IK(Ca)).
  • Increases KCNQ2/3 currents in CHO cells.
  • Potently augments KCNQ2/3 channels, shifting half-maximal activation voltage (V(1/2)) in hyperpolarizing direction.

Catalog No. 50-003-41574


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