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Apexbio Technology LLC QX 314 bromide 24003-58-5 100mg
Supplier: Apexbio Technology LLC B6547100
QX 314 bromide (CAS 24003-58-5) is a membrane-impermeant quaternary derivative of lidocaine that functions as a local anesthetic It blocks voltage-gated sodium channels inhibiting Na -dependent action potentials and non-inactivating sodium conductance as demonstrated in hippocampal CA1 pyramidal neurons In vitro QX 314 bromide modulates TRPV1 channels higher concentrations (10 60 mM) activate TRPV1 while submicromolar concentrations inhibit capsaicin-induced TRPV1 currents with an IC50 of 8 0 M When administered with flagellin it suppresses sodium currents in large-diameter human dorsal root ganglion neurons and inhibits mechanical allodynia in neuropathic pain models QX 314 bromide is utilized in studies on neuronal excitability pain mechanisms and long-lasting local anesthesia
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