Apexbio Technology LLC (R)-Crizotinib 877399-52-5 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A30205.1

(R)-Crizotinib (CAS 877399-52-5) is an ATP-competitive orally bioavailable inhibitor targeting c-Met kinase with a reported Ki of 4 nM It inhibits phosphorylation of wild-type c-Met in various endothelial and tumor cell lines at an IC50 of approximately 11 nM In cell-based assays the compound reduces proliferation and induces apoptosis in GTL-16 gastric cancer cells inhibits hepatocyte growth factor (HGF)-mediated migration and invasion of human NCI-H441 lung cancer cells and suppresses cell scattering growth (R)-Crizotinib demonstrates tumor growth inhibition efficacy across diverse xenograft models including gastric lung renal glioblastoma and prostate cancers highlighting its utility in oncology research

Catalog No. 50-000-63023