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Medchemexpress LLC (R)-(-)-Gossypol acetic acid | 866541-93-7 | C32H34O10 | 100 MG
Supplier: Medchemexpress LLC HY15464A100MG
(R)-(-)-Gossypol acetic acid, also known as AT-101 (acetic acid), is the levorotatory isomer of the natural product Gossypol. It functions as a Bcl-2 Family Inhibitor, binding to Bcl-2, Mcl-1, and Bcl-xL proteins with Ki values of 260±30 nM, 170±10 nM, and 480±40 nM, respectively. This compound demonstrates higher potency than (+)-Gossypol in inhibiting cell growth and inducing apoptosis, exhibiting superior growth inhibition in UM-SCC-6 and UM-SCC-14A cell lines compared to (+)-Gossypol.
- Bcl-2 family inhibitor
- Binds to Bcl-2, Mcl-1, and Bcl-xL proteins
- Induces apoptosis and inhibits cell growth
- Effective against head and neck squamous cell carcinomas (HNSCC) cell lines
- Induces apoptosis in HNSCC tumor cells with functional and mutant p53
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