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Medchemexpress LLC (R)-(-)-Gossypol acetic acid | 866541-93-7 | C32H34O10 | 5 MG
Supplier: Medchemexpress LLC HY15464A5MG
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is the levorotatory isomer of the natural product Gossypol. It is a research chemical that binds to Bcl-2, Mcl-1, and Bcl-xL proteins, making it suitable for studies in apoptosis and autophagy pathways.
- Purity of 98.93%
- Molecular weight of 578.61
- Chemical formula C32H34O10
- Appears as a solid, light yellow to brown
- Targets Mcl-1 (170 nM Ki), Bcl-2 (260 nM Ki), and Bcl-xL (480 nM Ki)
- More potent than (+)-Gossypol in inhibiting cell growth and inducing apoptosis
- Shows potent activity against head and neck squamous cell carcinomas cell lines in vitro
- Induces apoptosis in HNSCC tumor cells with functional p53 and kills mutant p53 tumor cells by a different mechanism
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