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Medchemexpress LLC R112 | 575474-82-7 | 98.9% | 312.30 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY1642050MG

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R112 is a fast and reversible inhibitor of spleen tyrosine kinase (Syk). It inhibits Syk kinase activity with an IC50 value of 226 nM and a Ki value of 96 nM. R112 also inhibits the IgE-FcεRI signaling pathway.

  • Inhibits Syk kinase activity
  • Inhibits IgE-FcεRI signaling pathway
  • Useful for research related to allergic rhinitis
  • Dose-dependently inhibits anti-IgE-mediated tryptase and histamine release
  • Inhibits secretion of LTC4, TNF-α, GM-CSF, and IL-8
  • Inhibits phosphorylation of the Syk target LAT (Y191)

Catalog No. 50-003-92355


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