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Apexbio Technology LLC R547 741713-40-6 10mg
Supplier: Apexbio Technology LLC A864210
R547 (CAS 741713-40-6) is a potent and selective inhibitor of cyclin-dependent kinases (CDKs) demonstrating a median Ki of 2 nM against CDK1/cyclin B CDK2/cyclin E and CDK4/cyclin D1 complexes By targeting CDKs which regulate cell cycle progression transcription mRNA processing and neuronal differentiation R547 effectively suppresses proliferation across a range of tumor cell lines regardless of tissue origin multidrug resistance status or p53 expression In xenograft models of colon lung breast prostate cancers and melanoma oral or intravenous administration led to marked tumor growth inhibition (TGI up to 99%) without detectable toxicity R547 is thus a valuable tool for studying CDK-dependent pathways and tumor biology
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