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ABclonal Technology Rab12 Rabbit mAb MJFF-A-3F6
Supplier: ABclonal Technology A2727520UL
Rab12 a member of the RAS oncogene family is crucial for intracellular membrane trafficking This small GTPase transports vesicles from recycling endosomes to lysosomes and is essential for autophagy and transferrin receptor degradation Rab12 cycles between inactive GDP-bound and active GTP-bound forms recruiting effectors for vesicle movement and fusion It is phosphorylated by LRRK2 (Leucine-Rich Repeat Kinase 2) and also regulates LRRK2 activity Rab12 activates LRRK2 which increases phosphorylation of Rab10 another trafficking protein especially in lysosomal damage Dysregulation of this pathway due to LRRK2 mutations is linked to neurodegeneration in Parkinson s disease
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