Medchemexpress LLC (Rac)-PF-998425 | 1076225-27-8 | 99.68% | C14H14F3NO | 10 MM X 1 ML

Supplier:  Medchemexpress LLC HY14250A10MM/1ML

(Rac)-PF-998425 is a potent, selective, nonsteroidal androgen receptor (AR) antagonist, exhibiting an IC50 of 26 nM in AR binding assays and 90 nM in cellular assays. It demonstrates low activity on common receptors and enzymes, including the progesterone receptor. This compound is suitable for research related to sebum control and androgenetic alopecia.

• Potent, selective nonsteroidal androgen receptor (AR) antagonist
• Exhibits IC50 values of 26 nM in AR binding and 90 nM in cellular assays
• Low activity on common receptors and enzymes, including progesterone receptor
• Suitable for research on sebum control and androgenetic alopecia
• Rapidly metabolized in rat liver microsomes (t1/2=4 min, CLint=350 (μL/min)/mg protein)
• Mean systemic plasma clearance is 40 (mL/min)/kg
• Mean apparent volume of distribution at steady state is 6.5 L/kg
• Mean terminal phase half-life is 2.6 hours

Catalog No. 50-003-55582