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BioVendor, LLC RBP4 Human ELISA
Supplier: BioVendor, LLC RAG005R
Retinol binding protein (RBP) 4 is the only specific transport protein for vitamin A in the circulation whose function is to deliver vitamin to target tissues. In obesity and type 2 diabetes, expression of Glut4 is significantly impaired in adipocytes. Glucose transport via Glut4 is the rate-limiting step for glucose use by muscle and adipose tissue. Yang et al. noted that adipocyte-specific deletion of Gluts led to notable elevation of RBP4 causing systemic insulin resistance, and that reduction of RBP4 improved insulin resistance. This identified a novel role of RBP4 in regulating insulin action and RBP4 is recorded as an adipocyte-derived hormone. Thus, measurement of serum or plasma RBP4 is a useful means for understanding metabolic disorders. This competitive ELISA (immobilized antigen) quantitatively measures RBP4 in human serum, plasma, urine, and cell culture supernatant. Cal range: 0.001-5µg/ml. LoD: 1ng/ml. Other names: Plasma retinol-binding protein, PRBP, PR002222.
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