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Medchemexpress LLC RBPJ Inhibitor-1 (RIN1) | 2682114-39-0 | 99.9% | 311.31 | 100 MG
Supplier: Medchemexpress LLC HY137471100MG
RBPJ Inhibitor-1 (RIN1) is the first inhibitor of RBPJ, functioning by blocking the interaction of RBPJ with SHARP. This inhibition suppresses NOTCH-dependent tumor cell proliferation. It is intended for research use only. In laboratory settings, this compound inhibits the proliferation of hematologic cancer cell lines and promotes skeletal muscle differentiation from C2C12 myoblasts.
- Blocks functional interaction of RBPJ with SHARP.
- Suppresses NOTCH-dependent tumor cell proliferation.
- Inhibits proliferation of hematologic cancer cell lines.
- Promotes skeletal muscle differentiation from C2C12 myoblasts.
- Induces formation of multinucleated myofibers.
- Exhibits IC50 of 0.18 μM for Hes1-Luciferase activity in AD-293 cells.
- Shows similar potency and efficacy against NOTCH3 ICD.
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