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Medchemexpress LLC Refametinib | 923032-37-5 | 99.8% | 572.34 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY14691100MG

Encompass_Preferred

Refametinib (BAY 869766; RDEA119) is an orally available, potent, non-ATP-competitive, selective, allosteric MEK1/MEK2 inhibitor. It selectively binds directly to an allosteric pocket in the MEK1/2 enzymes and potently inhibits MEK activity in enzyme inhibition assays.

  • Potent MEK1/MEK2 inhibitor with IC50s of 19 nM for MEK1 and 47 nM for MEK2
  • Active in human tumor xenograft models
  • Well tolerated within therapeutic exposure range in animals

Catalog No. 50-003-63559


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