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Apexbio Technology LLC RG 108 48208-26-0 25mg
Supplier: Apexbio Technology LLC A191325
RG 108 (CAS 48208-26-0) is a small-molecule inhibitor of DNA methyltransferases (DNMTs) It acts by directly blocking DNMT activity without forming covalent enzyme-adducts leading to DNA demethylation and consequent reactivation of epigenetically silenced tumor suppressor genes However RG 108 treatment does not affect methylation status of centromeric satellite DNA sequences In cellular models RG 108 promotes reprogramming efficiency especially enhancing induction of pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs) It is useful for studying epigenetic gene regulation tumor suppression pathways and cellular reprogramming mechanisms
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