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Apexbio Technology LLC RG2833 1215493-56-3 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A37615.1
RG2833 (CAS 1215493-56-3) is a small-molecule inhibitor targeting histone deacetylase (HDAC) In neuronal cell models RG2833 elevates frataxin (FXN) mRNA and protein expression by modifying epigenetic regulation at the FXN locus Studies conducted on peripheral blood mononuclear cells (PBMCs) from patients demonstrated reduced HDAC activity enhanced histone H3 lysine 9 acetylation and elevated FXN mRNA levels upon RG2833 treatment Research utilizing induced pluripotent stem cell (iPSC)-derived neuronal cultures further supports HDAC inhibition as the mechanism underlying RG2833-mediated FXN upregulation This molecule is primarily explored for epigenetic studies in Friedreich s ataxia research
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