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Apexbio Technology LLC RG7112 939981-39-2 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A37625.1

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RG7112 (CAS 939981-39-2) is a selective small-molecule inhibitor of the interaction between the tumor suppressor protein p53 and its negative regulator MDM2 By blocking MDM2-p53 binding RG7112 releases and stabilizes p53 thereby enhancing the transcriptional activation of genes responsible for cell cycle arrest and apoptosis RG7112 preferentially inhibits proliferation in cancer cells harboring wild-type p53 exhibiting IC50 values ranging from 0 18 to 2 2 M whereas its efficacy diminishes significantly in p53-mutant cells RG7112 is used as a tool compound in biomedical research investigating p53-dependent antitumor mechanisms and pathways affecting hematopoiesis

Catalog No. 50-000-64025


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