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Medchemexpress LLC Rho-Kinase-IN-2 | 2573071-18-6 | C20H25FN4O2 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1506405MG

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Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and CNS-penetrant Rho Kinase (ROCK) inhibitor with a ROCK2 IC50 of 3 nM. This compound is suitable for use in Huntington's research, demonstrating concentration-dependent effects in vitro and dose- and time-dependent target engagement in vivo.

  • Orally active, selective, and CNS-penetrant Rho Kinase (ROCK) inhibitor
  • ROCK2 IC50 of 3 nM
  • Suitable for Huntington's research applications
  • Increases AKT phosphorylation and decreases MYPT1 phosphorylation in cell studies
  • Shows dose- and time-dependent ROCK1 and ROCK2 target engagement in animal models
  • Exhibits excellent tolerability in mice models
  • Provides a direct dose- and time-dependent relationship between brain exposure and MYPT1 phosphorylation status
  • Decreases mean arterial, systolic, and diastolic blood pressure, and heart rate in CD1 mice

Catalog No. 50-003-75298


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